De Novo Design of a Single-Chain Diphenylporphyrin Metalloprotein
نویسندگان
چکیده
منابع مشابه
De novo design of a single-chain diphenylporphyrin metalloprotein.
We describe the computational design of a single-chain four-helix bundle that noncovalently self-assembles with fully synthetic non-natural porphyrin cofactors. With this strategy, both the electronic structure of the cofactor as well as its protein environment may be varied to explore and modulate the functional and photophysical properties of the assembly. Solution characterization (NMR, UV-v...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2007
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja071199j